Mammalian skin is an ideal model system to study fundamental questions in stem cell and cancer biology
Specialized stratified epithelia cover the body surface, where they serve as barriers against the outside environment. These epithelia rapidly turnover throughout life and are maintained by progenitors that reside within the deepest, basal layer.
Our lab is broadly interested in how these epithelia are established, maintained, and disrupted in disease. We utilize both the mouse epidermis and oral epithelia as model systems to study stratified epithelial development, stem cells and cancer.
AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis
Williams SE, Lough KJ. Current Biology (2020) 30(24):R1481-R1484.
Lough KJ, Spitzer DC, Bergman AJ, Wu JJ, Byrd KM, Williams SE. Development (2020) 13;147(21):dev189241.
Lough KJ, Byrd KM, Descovich CP, Spitzer DC, Bergman AJ, Beaudoin GM 3rd, Reichardt LF, Williams SE. Elife (2019) 13;8:e49249.
Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE. Cell Stem Cell (2019) 25(6):814-829.e6.
Carper MB, Troutman S, Wagner BL, Byrd KM, Selitsky SR, Parag-Sharma K, Henry EC, Li W, Parker JS, Montgomery SA, Cleveland JL, Williams SE, Kissil JL, Hayes DN, Amelio AL.
Cell Reports (2019) 29(6):1660-1674.e7. PMID: 31693903.
Lough KJ, Byrd KM, Spitzer DC, and Williams SE. J Dent Res (2017) 96(11):1210-1220.
PMID: 28817360. [Special Issue on Orofacial Clefting, Craniofacial and Dental Anomalies]
Byrd KM, Lough KJ, Patel JH, Descovich CP, Curtis TA and Williams SE. Development (2016) 143(15): 2803-17.
Williams SE, Beronja S, Pasolli HA and Fuchs E. Nature (2011) 470: 353-358.
View full list of publications here.
University of North Carolina at Chapel Hill
605 Brinkhous-Bullitt Building,
Chapel Hill, NC 27599