The mammalian skin epithelium is an ideal model system to study fundamental questions in stem cell and cancer biology
Specialized stratified epithelia cover the body surface, where they serve as barriers against the outside environment. These epithelia rapidly turnover throughout life and are maintained by progenitors that reside within the deepest basal layer. Our lab is broadly interested in how these epithelia are established, maintained, and disrupted in disease. We utilize both the mouse epidermis and oral epithelia as model systems to study stratified epithelial development, stem cells and cancer.
Lough KJ, Byrd KM, Spitzer DC, and Williams SE. J Dent Res (2017) 96(11):1210-1220. PMID: 28817360. [Special Issue on Orofacial Clefting, Craniofacial and Dental Anomalies]
Williams SE*, Garcia I, Crowther AJ, Stewart A, Li S, Stewart A, Liu H, Lough, KJ, O’Neill S, Veleta K, Oyarzabal EA, Merrill JR, Shi YI and Gershon TR*. Development (2015) 142(22): 3921-32. PMID: 26450969. *co-corresponding authors.
Williams SE and Fuchs E. Curr Opin Cell Biol (2013) 25(6):749–758. PMID: 24021274
View list of publications from PubMed
University of North Carolina at Chapel Hill
605 Brinkhous-Bullitt Building,
Chapel Hill, NC 27599